Lab Specific Gene Expression Signatures in Pluripotent Stem Cells

August 06, 2010

James D. Cooper, Associate Professor in the Molecular Cellular and Developmental Biology Department as well as the Biomolecular Science and Engineering Program at UC Santa Barbara was published in the August issue of Cell Stem Cell for his collaborative work with Aaron M. Newman using an unsupervised clustering algorithm called AutoSOME to study lab specific gene expression signatures in Human Induced Pluripotent Stem Cells(iPSC) and Human Embryonic Stem Cells(hESC). Reanalysis of microarray gene expression data from seven different laboratories shows strong correlation between gene expression signatures and specific laboratories in both ESC and iPSC lines.