Research

Organisms in all branches of the tree of life harness exotic cofactors, macromolecular dynamics, and elegant reaction design to enable chemical transformations that occur far from equilibrium. Research in the Greene lab seeks to elucidate how biomolecular non-equilibrium reaction control is achieved. We are specifically interested in oxidation/reduction (redox) reactions that occur at potentials outside the solvent “redox window” of water that are relevant to bioenergy, biogeochemistry, and human health. Discoveries in these areas are enabled by a dynamic team of investigators of diverse expertise and a synergistic approach involving traditional and cutting-edge methods in protein engineering, molecular biology, spectroscopy, electrochemistry, and biomolecular structural analysis.