A second goal of the Center is to investigate novel methods for stem cell growth, differentiation, sorting and delivery, using high throughput methods, novel assays, and innovative instruments for future applications of stem cell therapies.
The Dewey Lab engineers cellular signals for regenerative medicine. We combine biomaterials with extracellular vesicles, which are nano-sized lipid encapsulated cargo secreted by cells for cell-signaling purposes. Specifically, we focus much of our effort on the understanding and application of a new class of extracellular vesicle in regenerative medicine, a type of vesicle found residing in the extracellular matrix termed matrix-bound nanovesicles (MBV).
Dr. Siddharth Dey's research focuses on single cell genomics and epigenomics
Organisms in all branches of the tree of life harness exotic cofactors, macromolecular dynamics, and elegant reaction design to enable chemical transformations that occur far from equilibrium. Research in the Greene lab seeks to elucidate how biomolecular non-equilibrium reaction control is achieved. We are specifically interested in oxidation/reduction (redox) reactions that occur at potentials outside the solvent “redox window” of water that are relevant to bioenergy, biogeochemistry, and human health. Discoveries in these areas are enabled by a dynamic team of investigators of diverse expertise and a synergistic approach involving traditional and cutting-edge methods in protein engineering, molecular biology, spectroscopy, electrochemistry, and biomolecular structural analysis.
Macromolecular synthesis, metal-free atom transfer radical polymerization, new building blocks for polymer electronics materials, sequence-controlled polymers using macrocyclic ROMP, ionically-driven coacervate hydrogels, and functional polyethers
Fundamental fluid mechanics at the micro-scale and nano-scale, transport issues in MEMS-based sensors, combining surface-enhanced Raman Spectroscopy with microfluidics, and experimental and numerical simulation tools developed and utilized to investigate transport processes at the micro and nanoscales.
Operator-theoretic approach to analysis of nonlinear dynamical systems, applications in microfluidics and (bio)-nanotechnology.
Our research begins at the intersection of materials science, physics, chemistry, and biology, and aims to understand interfacial phenomena and energy-dissipation at the interfaces of soft materials. We focus on friction, adhesion, wear, and deformation of complex surfaces - from living cells to polymer nanocomposites. These interfacial interactions transpire over multiple length- and time-scales, often in extreme environments and within buried interfaces. Students in our group will acquire proficiency in a wide array of in situ experimental techniques (e.g., microscopy, spectroscopy, and interferometry) to access these interfaces and gain mechanistic insights into dynamically evolving material systems. The immediate impacts of these research efforts are in healthcare, energy, sustainability, and engineering design.
Vascular Zip Codes, Cell Attachment and Anoikis, and Nanomedicine.
Synthesis of mesoporous materials and their applications, with extensive collaborations with various research groups around the campus of UCSB conducting research in the areas of marine science, biological, bioinorganic, inorganic, solid state, materials, and physical chemistry.Organic/inorganic interface chemistry.
Nanoscale manipulation and measurement techniques to probe how forces are generated and transmitted in living materials, and how these forces control cellular outcomes. Understanding the mechanical properties of the cytoskeleton as well as the biophysical and biochemical basis of cellular mechanics.
Neuroscience Research Institute
University of California, Santa Barbara
Santa Barbara, CA 93106-9610
