Targeted areas include the generation of ocular cells for the treatment of eye disease; neural cells that might prove therapeutic for Alzheimer's Disease and Parkinson's disease, and pancreatic cells for applications in diabetes. These projects will include delivery of stem cells in animal models of disease, and will be facilitated by partnering with clinical researchers at other institutions.
The Clegg Laboratory focuses its research on the molecular basis of neural development and disease; retinal development and degeneration; differentiation of ocular cells from embryonic and adult stem cells.
My research interests lie in understanding the parameters that govern the action of cellular components of the nervous system that produce coordinated behavioral, endocrine, and cognitive processes. The focus of my current research is the functional consequences of and mechanisms that govern neurogenesis in the adult mammalian brain.
We work on neural plasticity including the molecular basis of plasticity, the evolution of synapses, and disease-related impairments of plasticity such as occurs in Alzheimer's disease.
Research in the Weimbs Laboratory is centered around Autosomal-dominant polycystic kidney disease (ADPKD), SNAREs, and epithelial cell polarity.
Neuroscience Research Institute
University of California, Santa Barbara
Santa Barbara, CA 93106-9610
